Sensing of peptide hormones with dynamic combinatorial libraries of metal-dye complexes: the advantage of time-resolved measurements.
نویسندگان
چکیده
A dynamic combinatorial library of metal-dye complexes was obtained by reacting aqueous solutions of the dyes Methyl Calcein Blue, Arsenazo I, and Xylenol Orange with CuCl(2) and NiCl(2). The mixture gave a characteristic UV-Vis response upon addition of the peptide hormones angiotensin I and angiotensin II. This allowed distinguishing pure samples of peptide hormones from mixtures. The discriminatory power of the sensor was enhanced when the several UV/Vis measurements were performed during the equilibration process of the library.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 22 شماره
صفحات -
تاریخ انتشار 2009